Wednesday, June 2, 2010


This listing of modifiers is intended for reporting with molecular laboratory procedures related to genetic
testing. Genetic test modifiers should be used in conjunction with CPT and HCPCS codes to provide
diagnostic granularity of service to enable provider to submit complete and precise genetic testing
information without altering test descriptors. These modifiers are categorized by mutation. The first
(numeric) digit indicates the disease category and the second (alpha) digit denotes gene type. Introductory
guidelines in the molecular diagnostic and molecular cytogenetic code sections of CPT provide further
guidance in interpretation and application of genetic test modifiers.

Neoplasia (solid tumor)

0A BRCA1 (Hereditary breast/ovarian cancer)
0B BRCA2 (Hereditary breast cancer)
0C Neurofibromin (Neurofibromatosis, type 1)
0D Merlin (Neurofibromatosis, type 2)
0E c-RET (Multiple endocrine neoplasia, types 2A/B,
familial medullary thyroid carcinoma
0F VHL (Von Hippel Lindau disease)
0G SDHD (Hereditary paraganglioma)
0H SDHB (Hereditary paraganglioma)
0I Her-2/neu
0L APC (Hereditary polyposis coli)
0M Rb (Retinoblastoma)
1Z Solid tumor, not otherwise specified

Neoplasia (lymphoid/hematopoetic)

2A AML1 – also ETO (Acute myeloid leukemia)
2B BCR – also ABL (Chronic myeloid, acute lymphoid
2D CBF beta (Leukemia)
2E ML (Leukemia)
2F PML/RAR alpha (Promyeleocytic leukemia)
2G TEL (Leukemia)
2H bcl-2 (Lymphoma)
2I bcl-1 (Lymphoma)
2J c-yc (Lymphoma)
2K lgH (Lymphoma/leukemia)
2Z Lymphoid/hematopoetic neoplasia not otherwise


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